DSIP Compound

LOG 08 / SOURCES

DSIP references and source log

Every study cited in this digest, with full bibliographic detail and PubMed links.

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About these references

Every quantitative claim in this DSIP digest, each dose, percentage, duration, and outcome, maps to a numbered source below. The list spans the foundational 1977 characterization, the 1980s and 1990s European human insomnia trials, the neuroendocrine and pineal studies, the rodent longevity work, and the 2024 fusion-peptide study, drawn from PubMed-indexed journals. Each entry carries its authors, journal, year, volume, pages, and a PMID or DOI so the original can be located and read in full.

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. ↗
  2. Schneider-Helmert D, et al. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(8):913-914. ↗
  3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. ↗
  4. Bjartell A, Ekman R, Bergquist S, Widerlov E. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. ↗
  5. Popovich IG, Voitenkov BO, Anisimov VN, et al. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. ↗
  6. Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Front Pharmacol. 2024;15:1439536. ↗
  7. Schneider-Helmert D. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992;26(4):230-233. ↗
  8. Schneider-Helmert D. Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. Eur Neurol. 1987;27(2):120-129. ↗
  9. Schneider-Helmert D. A clinical trial with DSIP. Eur Neurol. 1984;23(5):358-363. ↗
  10. Schneider-Helmert D. Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs. Eur Neurol. 1986;25(2):154-157. ↗
  11. Schneider-Helmert D. The use of DSIP (delta sleep-inducing peptide) in the correction of phase-shifted insomnia. Dtsch Med Wochenschr. 1987;112(20):779-783. ↗
  12. Vorob'ev VV, Shibaev NV, Prudchenko IA, Mikhaleva II. [The frequency composition of the brain electrical activity in rats after the use of the delta-sleep peptide and its analogs]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1992;42:977-985. ↗
  13. Gupta BB, Seidel A, Spessert R, et al. In vitro effects of putative neurotransmitters on synaptic ribbon numbers and N-acetyltransferase activity in the rat pineal gland. J Neural Transm Gen Sect. 1992;89:167-178. ↗
  14. Sudakov KV. [The antistress effects of the delta sleep-inducing peptide]. Fiziol Zh SSSR Im I M Sechenova. 1991;77:1-13. ↗
  15. Bjartell A, Sundler F, Ekman R. Immunoreactive delta sleep-inducing peptide in the rat hypothalamus, pituitary and adrenal gland: effects of adrenalectomy. Horm Res. 1991;36:52-62. ↗